ABSTRACT
Chlorogenic acid (CGA) is a polyphenolic compound widely distributed in the diet. It has been shown to have a variety of potential
health benefits and is also administered as a food supplement. However, the report on its safety assessment is sparse. This study is
therefore designed to assess the effect of acute exposure to CGA. Forty-eight
Swiss mice were weight-matched
into eight groups
(n = 6). Groups I and II received distilled water and 1% ethanol; Groups III–VIII received 30, 60, 120, 240, 480 and 1000 mg/kg
doses of CGA, respectively. Twenty-four
hours post-treatment,
the liver and kidneys were excised and used for antioxidant assays
and kidney and liver function tests. Sections were prepared for histology. Results showed that the concentration of hydrogen
peroxide was significantly elevated at all the doses of CGA in the kidney and also in the liver. The liver function parameters were
affected in the liver of mice treated with CGA. CGA variably affected potassium ion concentration at the different doses in the
kidney. Results were complemented by the histology. CGA manifests a deleterious effect, as evidenced by the perturbations in
some of the biochemical parameters in the liver at all the doses, and in particular from the 240 mg/kg dose.
Detection of Antibiotic Resistance Genes in Salmonella, Klebsiella and Shigella species from Household Water Sources in Ibadan
Research Summary Feco-orally transmitted infectious diseases are common in Nigeria, where potable water access is